Research Details
Pharmadens OsteoTherapy™
Mineral Support Formula
ProMineral Balance For Implantology, Oral Surgery, And Periodontal Surgery

Periodontal Formulas
Physician Information
by Clark Hansen, N.M.D.

Periodontal Disease

Orthodontics and Oral surgery creates unique demand for specialized mineral support to prevent osseous complications. Bone remodeling induced by orthodontics and oral surgery can, if left untreated, weaken the integrity of the bones of the maxilla or mandible and possibly increase the incidence of osteoporosis later in life

Bone accumulation and structure during growth, as well as bone loss or deposition in adults, are greatly affected by mechanical stress. The procedures involved in orthodontia and oral surgery create a biomechanical stress that leads to remodeling of the bone. The initial step involves activation of osteoclasts that breakdown the discrete segment of bone under biomechanical stress. The second step involves resorption of the bone. During the third step, new bone is formed by osteoblasts in the resorption cavity to occur This activation, resorption, formation sequence of remodeling takes about four months.2 Implant dentists report similar time frames for remodeling and osseointegration to occur with implants

In order to achieve optimal results in the shortest period of time during this remodeling phase it is critical to ensure the supply of the essential components of remineralization. This is particularly important during adolescence, when Growth Hormone (GH) enhances mineral retention and deposition in bone, 3 creating a bone reservoir against later bone loss. Adult patients also require supplemental mineral support due to the lower initial bone density and inferior capacity for remineralization that increases with age.

In the United States, at least 25 million people suffer from osteoporosis. In women bone mass begins to decline at approximately age 35, then accelerates rapidly for 8-10 years around the time of menopause. By the time of diagnosis, 50 to 75% of the original bone material has already been lost. Supporting the remineralization process simultaneous to orthodontic and oral surgical procedures will ensure more successful results and help to prevent the promotion of bone loss or bone reservoir depletion.

Conventional Therapy
Conventional orthodontic and oral surgical procedures have not addressed bone remineralization. This has lead to several significant adverse results including demineralization; mucogingival and marginal attachment bone loss, as well as devitalization of teeth. 1 No conventional therapy has been routinely employed to prevent bone demineralization associated with orthodontics or oral surgery.

Functional Therapy
Pharmaden LLC, the leader of functional medicine in dentistry, has developed a unique proprietary formulation that significantly enhances bone remineralization. OsteoTherapy is an all-natural nutritional supplement designed to assist the body to efficiently restore optimal density to the alveolar bone involved in the procedures of orthodontia and oral surgery.

NEW and improved OsteoTherapy+

Ingredients per 2 capsules

Vitamin C (Ascorbic Acid) 75mg
Vitamin D3 (Cholecalciferol) 800IU (20mcg)
Vitamin K2 (MK4/MK7) 60mcg
Folate (as 120 mcg Folic Acid) 200mcg DFE
Vitamin B12 (as Methylcobalamin) 20mcg
Calcium (426mg Elemental as Calcium Citrate) 1114mg
Magnesium (120 Elemental as Magnesium Oxide) 197mg
Zinc (7.5mg Elemental as Zinc Picolinate) 36mg
Copper (1mg Elemental as Copper Gluconate) 7mg
Manganese (1.2mg Elemental as Manganese Glycinate) 9mg
Grape Seed Extract 99% 25mg
Silicon (as Silicon Dioxide) 5mg
Boron (as Boron Aspartate) 0.25mg

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Benefits at a Glance:

· Highly absorbable nutrients for greater bone density

· Provides three different forms of calcium

· Includes magnesium, boron, zinc, manganese, copper, and silicon

· Contains 800IU of vitamin D3 per serving

· Provides vitamin K2 as menaquinone-7

We all know calcium helps maintain bone density and strength. But what you might not realize is that dietary calcium requires adequate amounts of other vital nutrients in order for it to be most effective. That’s why we’ve paired an easily absorbable calcium with vitamin D3, K2, and other essential bone-healthy minerals.

Most people don’t get enough dietary calcium to offset that which is lost in the course of aging. Additionally, many forms of calcium are not well-absorbed. Calcium citrate is highly absorbed and delivered in a capsule that ensures full breakdown during digestion.

Vitamins K2 and D3
Vitamin D is essential for absorbing calcium from the digestive tract into the bloodstream. And Vitamin K2 helps maintain bone density by promoting calcium transport from the bloodstream into bone. Thus vitamin D3 and vitamin K2 are essential for helping maintain strong, healthy bones and teeth.

Magnesium, zinc, and other bone-healthy minerals
Magnesium is needed to maintain strong bones and a healthy vascular system. OsteoTherapy+ with Vitamin K2 contains 197 mg of magnesium from magnesium oxide. Zinc, manganese, and silicon are essential for healthy bone maintenance. You have to have sufficient intake of these elements to support healthy bone formation. Boron is a trace mineral with beneficial effects for bone and joint strength.

Adding OsteoTherapy+ with Vitamin K2 to your whole-body health regimen is a great way to get all of these critical, bone-healthy nutrients in a single, convenient formula.

Minerals and Vitamin Cofactors
Inorganic salts, comprise more than 70% of the matrix of bone. The major component of the extracellular organic matrix is collagen, which comprises more than 90% by weight. The intricate arrangement of collagen fibers and mineral crystals gives bone its incredible tensile strength.

The trace mineral boron Helps direct calcium, magnesium, and vitamin D into the bones to maintain bone density. Studies indicate that boron directly effects the action of parathormone resulting in significant alterations in calcium, magnesium, cholecalciferol and phosphorus metabolism. Boron is required to activate certain hormones including estrogen, testosterone, and vitamin D. Fruits and vegetables are the main sources of boron. Diets that are deficient in these foods may also be deficient in boron. Oral supplementation of boron is extremely safe when administered in the recommended dosage range of 1 to 3 mg per day. Extremely high doses greater than 500 mg per day can cause nausea, vomiting and diarrhea.

B12, and Folic acid (natural form folate) are essential co-factors in the conversion of the amino acid methionine into cysteine. If they are deficient, homocysteine increases. As homocysteine increases in the body it interferes with collagen cross-linking, leading to a defective bone matrix, unable to hold calcium in its normal arrangement in the bone. These nutrients are in this way essential to the building of healthy teeth and bones and in the prevention of osteoporosis. Vitamin B12 helps to prevent anemia

Folic Acid: All of Pharmaden’s products use natural occurring form of folic acid called folate. It decreases homocysteine levels which can cause bone loss. Alcohol and Birth Control Pills cause a deficiency. Pregnancy creates a higher demand. The mouth has one of the highest cell turnover rates in the body. Folate plays a major role in DNA synthesis and repair. Folic acid supplementation should always include vitamin B12 because folic acid can mask an underlying vitamin B12 deficiency. Although folic acid can reverse the macrocytic anemia, it does not prevent or reverse the neurological symptoms associated with a deficiency of Vitamin B12. Otherwise both of these two vitamins are devoid of toxicity.

Vitamin C (Ascorbic Acid): A powerful antioxidant and anti-inflammatory, meaning it helps eliminate inflammation that causes bone loss. Cannot be produced by the body so it must be obtained in other forms. It can strengthen the immune system and help improve absorption of iron in the body. It may help reduce high blood pressure, high levels of LDL cholesterol, low levels of HDL cholesterol and triglyceride levels – all factors that increase the risk of heart disease.

Calcium is the major mineral in bones. However, too much calcium inhibits magnesium, which is essential to the production of the hormone calcitonin. Calcium supplements are generally well tolerated at dosages less than 2,000 milligrams (this is referring to elemental calcium). Higher dosages may increase the risk of kidney stones and soft-tissue deposition. When a patient is advised they need 1,000 mg of calcium a day, this is referring to elemental calcium not calcium citrate, calcium carbonate, etc., which are different forms of calcium. This does not mean that a supplement containing 1,000 mg of elemental calcium is needed as you consume calcium in your normal diet. It is recommended, instead, to take a supplement that is 25-60% of the 1,000 mg of elemental calcium, depending on eating habits. Always consult your health professional before taking any medication or supplements.

Calcium Citrate: Calcium is the major mineral in bones. Calcium Citrate is 400% better absorbed than Calcium Carbonate, even in individuals with low stomach acid. Not all calcium supplements are created equal. Pharmaden’s OsteoTherapy+ contains the more expensive, higher absorbing form of calcium citrate.

Copper: Being deficient in copper is linked to a dramatic decrease in bone density. It is an anti-inflammatory that helps strengthen supportive structures of the muscular system.

Vitamin D is safe in doses under 1,000 I.U. per day. Vitamin D3 (Cholecalciferol) is the natural form of vitamin D and used in OsteoTherapy+. It is necessary for normal bone growth and remodeling, in addition to aiding calcium absorption.

Vitamin K2 (MK4/MK7): The natural form of vitamin K2. Activates vital proteins for the development of healthy bone. Being low in vitamin K is a known risk factor for osteoporosis. When combined with vitamin B12 and folate it can prevent elevated levels of Homocysteine (a factor in the development of Arteriosclerosis). Vitamin K is required for the attraction of calcium to bones. Individuals with weak bones have been found to have 35% less Vitamin K than age matched controls. Overuse of antibiotics kills healthful intestinal flora that produce Vitamin K. Supplementation reduces calcium loss by as much as 18-50%.

MK4 – Recent studies show taking vitamin D, calcium, and magnesium supplements did not have a significant decrease in bone fractures and, instead, taking MK4 with calcium and vitamin D did significantly lower bone fractures. MK4 stopped and reversed bone loss, grew stronger bones, and reduced fractures more than 80%.

MK– Shown to reduce fractures and maintain bone density.  K2-7 safely directs calcium to your bones instead of your arteries (so arteries do not harden).7

Magnesium is also essential for the conversion of the active form of vitamin D, which is required for calcium absorption and its deposit into bone. Taking too much calcium actually blocks magnesium and therefore blocks the production of vitamin D in its active form, which prevents calcium from getting into the bone. Calcium should not be taken in excessive amounts relative to magnesium. Magnesium is generally well tolerated, however, supplementation of magnesium chloride, magnesium hydroxide, or magnesium citrate are sometimes associated with loose stools. OsteoTherapy+ uses magnesium oxide. Magnesium assists in the development and maintenance of healthy bones and reduces the rate at which your bones degrade. It is essential for bone and teeth structure. In 2005-2006, research shows that 48% of Americans consumed less than the required amount. Low levels have been linked with several diseases, including heart disease and osteoporosis. Too little of magnesium has been shown to cause calcium deficiency and inflammation in bones.

Manganese Glycinate: Essential for bone development and maintenance. When combined with calcium, zinc and copper (all found in OsteoTherapy+) it supports bone mineral density. It is composed of trace mineral manganese and an amino acid, glycine. It is easily absorbable. It helps the body in a variety of ways including formation of clotting factors, connective tissue, sex hormones, and bones. It helps in the absorption of calcium and metabolism of carbohydrate as well as fat. It plays an important role for normal nerve and brain function. Moreover, it is a component of the enzyme, superoxide dismutase which helps fighting free radicals. Decreased manganese level can cause infertility, seizures, weakness and bone malformation.

Silicon is required for optimal bone hydroxyprolase activity and plays an essential role in the crosslinking mechanisms involved in collagen, elastin and mucopolysaccharide formation. Certain bioflavonoids found in fruits have been shown to be very important in the prevention of bone loss. Proanthocyanidin bioflavonoids, especially those extracted from vitis vinifera (grape) seeds, have been shown to stabilize the collagen structures that knit bone together. The inclusion of these essential flavonoids is necessary to protect the integrity of collagen, including that found in the bone matrix. Silicon is generally recognized as nontoxic. It assists calcium to encourage bone growth and prevents deformities in bones.

Vitis vinifera (Grape) Seed Extract: Standardized extract of Proanthocyanidin bioflavonoids necessary for the proper formation of the bone/collagen matrix of the jaw. Pharmaden contains a unique and expensive Grape Seed Extract (GSE), 99% polyphenols – GSE can improve blood flow and may help reduce high levels of LDL cholesterol. Vitis vinifera seed extract has been shown to be devoid of any toxic, carcinogenic, or teratogenic effects. It does not impair fertility and has been shown to be safe for use during pregnancy and breast-feeding with no peri-natal or post-natal toxicity. Due to its bitter nature, occasional nausea or stomach upset has been reported. Temporary skin irritation has occurred in patients with a specific hypersensitivity to grapes. Chronic toxicity studies have shown it to be safe even at extremely high doses (132mg/lb body weight/day for twelve months in dogs), LD50>4000 mg/kg in rats and mice.

Zinc Picolinate is a well-absorbed form of zinc. It is also an immune booster that reduces depression, reduces risk of prostate cancer, helps prevent and treat live disease & cirrhosis, decreases risk of age related chronic disease, helps prevent age related macular degeneration, improves fertility in mails, shorten course of diarrhea, improves memory


Take two capsules twice daily or as directed by your dentist.



Zinc picolinate

Manganese glycinate

Manganese glycinate

MK4/MK7 in RA patients study:

Vitamin K2:

Vitamin K2:



Vitamin D3 vs D2:

Vitamin B12:

Vitamin deficiencys:

Magnesium hydroxide


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*x-ray images seen on this page are from patients taking the original OsteoTherapy product.